PSA is released into semen but some also enters the bloodstream. In conclusion, the issues discussed do not apply to the vast majority of cards that filter through the PSA grading process each day but this is an issue that needed some clarification in the marketplace. Visible loss of original gloss may be acceptable. The bottom line is that there are times when a PSA grader must make a call on a card that falls on the line between two grades and that final determination is made based on experience, eye appeal and market acceptability. A PSA NM 7 pack is a pack that exhibits similar attributes to a PSA NM-MT 8 but it may possess one or more of the following flaws: there may be slight wear on all four corners, a few pin-hole sized tears on the corners or edges, a very minor tear in the wrapper itself, light toning or soiling on the seal, and/or a small stain, possibly due to water or mildew damage. N-4 Questionable Authenticity - This is the term used when a card appears to be counterfeit or when the autograph is deemed to be not genuine. A PSA Good 2 must be close in nature to a VG 3, but up to two of the following additional defects may be present: two or more medium-to-heavy surface creases may be present, and this ticket may also show noticeable warping. There are instances where wrapper centering issues are the norm. For example, there will not be cards graded PSA NM-MT-Plus 8.5 OC or PSA EX-MT-Plus 6.5 PD since the half-point is reserved for high-end cards within each grade. The ticket may show some obvious, mid-range to dark staining in a limited area on the front or back. About 25 percent of men with a PSA between 4 and 10 have prostate cancer. Generally speaking, a card must exhibit centering that is 5-10% better, at minimum, than the lowest % allowed within a particular grade. As a marker for known disease, PSA level is very reliable for most patients. Hi Craig, I also like you was diagnosed with prostate cancer over six years ago. What a promise that is, but do we understand the true meaning and have the right interpretation for this verse? The areas/defects that PSA graders focus on include but are not limited to: scratches, dents, severity of rust (if present), centering of the picture (obverse and reverse), compression of the pin/coin, the overall condition of the paper (if present) on the reverse and overall print quality. For this reason, measurement of PSA in the blood has been used as a screening test for prostate cancer. Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene.PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland.. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. Even though the card may be heavily worn, it cannot achieve this grade if it is missing solid pieces of the card as a result of a major tear, etc. Free PSA: When total PSA is in the range of 4.0-10.0 ng/mL, a free PSA of less than 10 percent raises the likelihood that prostate cancer is present depending on age; whereas a high free PSA (more than 25 percent) indicates a low risk of prostate cancer, depending on age. Finally, let’s look at each of the 10 PSA grades. With the exception of the aforementioned items, normal grading criteria will apply. So that elevated PSA can be in many prostate diseases. Results most often come back within several days. This would include damage such as the removal of the back layer of the card or an entire corner. (Post Cereal, Hostess, Bazooka, Strip cards, etc.) A PSA Gem Mint 10 pack is a virtually perfect pack that should exhibit pristine corners and edges, which are free of any holes, tears or wear of any sort (including not having any wear to the corner folds). The rest of the cards crossed to their comparable grade PSA 10 to bgs 9.5, etc. This is a rare occurrence but it does happen. A PSA PR-FR 1 will appear obviously abused: the ticket's corners and edges exhibit pronounced and extreme wear. ), an exception may be made to allow an otherwise slightly off-center card to fall within an unqualified grade (no OC qualifier). Grading fees are not charged in this instance. A fold or full crease may exist and extend or cross over the entire ticket. A PSA level of less than 10 ng/mL is considered to indicate a low risk of aggressive disease. The cells in a man’s prostate gland — which, like all cells in the human body, are constantly dying and being replaced — produce a substance called prostate-specific antigen, or PSA. A person’s risk of high PSA levels may increase with age. Centering must fall within approximately 65/35 to 70/30 or better on the front and back. This can be measured in the PSA test. The surface quality may be subject to three or more light-to-medium surface creases; this ticket may also show some warping. All of the cards eligible for this service will be designated as "Hand-Cut" on the PSA label to distinguish them from the intact, "with tab" or "with coupon" examples. The original gloss may be entirely absent. Prostate-specific antigen (PSA) is a protein produced by the prostate that is used to track progression of known prostate cancer. If the cut exceeds the visible border for the card in question, PSA will encapsulate the card as "Authentic" only. grade NM 7 or better. I am inclined to ask for a prescription for 10 days and then have the PSA redone again in September. A PSA Fair 1.5 card's corners will show extreme wear, possibly affecting framing of the picture. Finally, keep in mind that qualifiers will not apply to grades that achieve the half-point increase since, by definition, these cards have to exhibit high-end qualities within the grade in order to warrant consideration. In addition, the pack must be "fresh" in appearance and free of any water or mildew damage to the wrapper or gum in order to qualify for this grade. The reverse seal may have soiling or toning as a result of water or mildew damage, as long as it is not deemed severe. In order to achieve a Fair grade, a card must be fully intact. A minor printing blemish is acceptable. A level of 10-20 ng/mL indicates intermediate risk and a level greater than 20 ng/mL suggests a high risk of cancer progression. Being that PSA is reported with such sensitivity (.01 increments) every PSA whole digit would appear statistically significant for prognosis outcome i.e., PSA 9.5 vs. PSA 10.5. AA Authentic Altered - This means that while PSA is certifying that the item is genuine, due to the existence of alterations, the item cannot receive a numerical grade. There may be an allowance made for a small printing imperfection as long as the pack still shows superb eye appeal. Note: This is the highest grade a pack can receive if the wax wrapper is a complete manufacturer miswrap, where there is a severe centering imperfection to the wrap. A slight surface "dimple" may be allowed if extremely limited. The 1955 Koufax card has a yellow background that tends to blend with the border of the card. There’s really a lot to discuss with a nine. What is your opinion. Defects such as general wear; print defects, loss of original gloss and paper loss on the reverse may be slightly more severe. As expected, the more severe and less defined the tear/removal, the lower the grade of the stub. Note: This is also the highest grade a cello pack can receive if the top card is 100/0(miscut). Centering must be approximately 65/35 to 70/30 or better on the front and 90/10 or better on the reverse. The results are usually reported as nanograms of PSA per milliliter (ng/mL) of blood. For example, while most cards fall clearly within the centering guidelines for a particular grade, some cards fall either just within or just outside the printed centering standards.The key point to remember is that the graders reserve the right, based on the strength or weakness of the eye appeal, to make a judgment call on the grade of a particular card. My psa was 70 with a gleeson score of 3+3. Otherwise, as stated above, a label of "Authentic" will be assigned or, in some cases, the cards may fall short of the size requirement altogether. Psa 10s ARE NOT in better condition overall than 9.5. The first thing to do is talk to your doctor about the pros and cons of prostate cancer screening before you decide whether to be tested. Very light "touches" at two corners, apparent to the naked eye, would be acceptable under this standard. A PSA Gem Mint 10 card is a virtually perfect card. The card may have light scuffing or light scratches. When the PSA level is above 10 ng/ml, risk of prostate cancer is much higher. The level of PSA is measured in nanograms per milliliter (ng/mL) of blood. Certification numbers appear in the lower right of the encapsulated label or on the oval DNA sticker. A Poor card may be missing one or two small pieces, exhibit major creasing that nearly breaks through all the layers of cardboard or it may contain extreme discoloration or dirtiness throughout that may make it difficult to identify the issue or content of the card on either the front or back. Crossover. This approximates real-world experience that during the first few years, mortgage borrowers: The seal may be misaligned and partly raised but a somewhat sizeable portion of that original seal must remain intact. PSA will not grade cards that bear evidence of trimming, re-coloring, restoration, or any other forms of tampering, or are of questionable authenticity. Multiple creases, scratches, non-game related punctures and extreme warping may be present. A ticket of this quality will appear to be a Mint 9 at first glance but one of the following additional defects may be present. If your PSA level is high, your doctor may suggest that you get a prostate biopsy to test for cancer. A ticket of this quality will appear to be a NM-MT 8 at first glance but one of the following additional defects may be present. Prostate-specific antigen (PSA) is a protein produced exclusively by prostate cells. - But then again PSA appears to be fickled at times - low PSA - High Gleason (7s , 8 or 9) - or - High PSA - Low Gleason (3 + 3) but these casses appear to be outliers. The best way to define the subjective element is to do so by posing a question: What will the market accept for this particular issue? In addition, PSA will allow cards that have had a coupon or tab removed from the original card to be submitted under this service. Normal PSA level is from 4.0 – 10.0 ng/ml, sometimes called “the grey zone”. Medium-to-heavy staining, and/or loss of print in one to two areas, on the front or back, may exist. A very light scratch may be detected only upon close inspection. Levels above 4 ng/mL but less than 10 ng/mL are considered suspicious. Picture focus may be slightly out-of-register. PSA tests measure a protein in your blood called prostate specific antigen. Three non-game related punctures or holes may be present. ", Cards with writing, ink marks, pencil marks, etc. PSA is a protein produced by both cancerous and noncancerous tissue in the prostate, a small gland that sits below the bladder in men.PSA is mostly found in semen, which also is produced in the prostate. Cards that exhibit a clean, accurate and properly shaped cut have the best chance at achieving the highest grades. Submitters will have the option of choosing not to have a grade assigned to the tickets and, instead, merely have the tickets authenticated and encapsulated. However, the value of PSA as a tool for prostate cancer screening has long been a controversial subject. There are, however, some unique condition obstacles that many packs are subject to. For example, a 1957 Topps Sandy Koufax card has great contrast between the white borders and the picture because the background is very dark. A small allowance may be made for very light gum bleeding or soiling through the wrapper, not to reach the size of the gum contained within. ... At the same time, low-level of prostate-specific antigen also does not rule out the possibility of cancer. A good card may have scratching, scuffing, light staining, or chipping of enamel on obverse. A free PSA test measures the level of prostate-specific antigens that are not bound to other proteins in the blood. Generally speaking, your PSA level should get very low after treatment. There are reasons doctors don’t agree on whether you need this test: Although the PSA test is used mainly to check for prostate cancer, it can also help your doctor: If you choose a watchful waiting approach to treatment, your PSA level can tell your doctor if the disease is progressing. In addition, the pack must be "fresh" in appearance and free of any water or mildew damage to the wrapper or gum to qualify for this grade. At this time, only cards qualify for half-point grades. PSA Grading Standards Using the Classic 1952 Topps Mickey Mantle, Want more visuals? You’ll need to talk to your GP or practice nurse about these before deciding whether to have a test. "Medium to Medium/Dark" printing of crucial game information is required. Newer PSA tests may help the doctor decide if you need a biopsy. However, most men who have this level of PSA do not have prostate cancer. The prostate-specific antigen (PSA) test is a blood test. Yes. A PSA level of less than 10 ng/mL is considered to indicate a low risk of aggressive disease. At this time, pins and coins will not receive half-point grades. 55 to 69: Screening if your doctor suggests, Over 70 or less than a 10-15 year life expectancy: No screening. Opinions differ about when you should do that. It is important to note that there may be cases where the overall strength of the card, such as the quality of the corners and print, will give the card the edge it needs despite the fact that it may exhibit only marginal centering for the grade. PSA Levels and their Meaning. Prostate cancer makes PSA levels go higher, but a high PSA test result doesn't always mean a … The PSA test is a blood test used primarily to screen for prostate cancer.The test measures the amount of prostate-specific antigen (PSA) in your blood. High PSA levels could be a sign of prostate cancer or a different condition like prostatitis or an enlarged prostate. Centering must be 80/20 or better on the front and 90/10 or better on the reverse. The study involved 773 men screened for prostate cancer who had a normalDRE but total PSA levels of 4 to 10 ng/mL. Autograph grades are determined using a grading scale of 1-10, with 10 being best, and are established based upon the quality of the signature as part of the autograph grading … However, the PSA test was first developed only to monitor men who had a history of prostate cancer. Focus of picture may be slightly out-of-register. And that is why this card received a 9 grade. Quality must be very close in nature to a Gem Mint 10 but the following allowances may be made. The PSA (prostate specific antigen) blood test can help detect or monitor prostate cancer. That wrapping may also be misaligned but, in order to qualify under this grade, a sizeable portion of the seal must remain secure. Centering must be 90/10 or better on the front and back. Several light scratches may be visible upon close inspection, but do not detract from the appeal of the card. Borders may be somewhat yellowed and/or discolored. Prostate-specific antigen (PSA) is a protein produced exclusively by prostate cells. Much, but not all, of the card's original gloss will be lost. N-2 Evidence of Restoration - When a card's paper stock appears to have been built up - for example, when ripped corners are built up to look like new corners. Excerpt from link below…"After the surgical removal of the prostate, or prostatectomy, PSA drops to virtually undetectable levels, (less than 0.1), depending on the lab performing the PSA test. A PSA Mint 9 pack is a pack that appears to have all the attributes of a PSA Gem Mint 10 but it may exhibit one of the following flaws: a slight touch of wear on one corner (absent a hole or tear in the wrapper), minor toning or soiling to the seal on the reverse or a slight centering imperfection to the wrap. However, it is important to remember that higher than normal levels of PSA indicate the vulnerability to prostate cancer and not the presence itself. N-6 Minimum Size Requirement - When a card is significantly undersized according to factory specifications. A minor printing defect is acceptable, such as "out of register" focus of graphic or text elements. Of concern is men with a rise of 2.0 ng/ml within one year. Packs found from the 1977 Topps football issue provide great examples of this frequently seen problem. Need Help? Minor loss of original gloss may be acceptable. When it comes to PSA, when you get your card graded a team of graders inspect the card for authenticity. On the other hand, PSA will grade a 1959 Bazooka or 1961 Post Cereal Mickey Mantle because those cards could only be obtained in one fashion - removed by hand from a box or panel. Then, the card is reviewed for any evidence of manipulation, or “card doctoring.”. This is a test where the doctor takes a small amount of tissue from your prostate and sends it to a lab for tests. These include but are not limited to obstacles such as gum and/or wax residue that can alter the overall freshness of a pack and, in turn, hinder the grade. Again, the vast majority of grading is applied with a basic, objective standard but no one can ignore the small (yet sometimes significant) subjective element. The gum or wax wrapper can begin to show bleeding or soiling through the wrapper, but it must be limited to the size of the gum. However, most men who have this level of PSA do not have prostate cancer. psa is an acronym and very useful on the online media. When the centering of the card falls below the minimum standard for that grade will be designated "OC." There’s no such thing as a normal PSA for any man at any given age, but most men with prostate cancer have a higher than normal level. Doctor wants to do biopsies. A fPSA of over 10% would mean that the most likely cause of the elevated PSA is not prostate cancer: a fPSA of under 10% is more strongly correlated with prostate cancer. The scale is covered more extensively on the Grading Standards page. Prostate-specific antigen (PSA) is a protein produced by the prostate gland. The factors above represent the basic, key elements in the PSA grading approach. There may be several creases. PSA will not grade any pack that has been deemed by the experts to be resealed, repaired or altered in any way. In fact, the pack may show signs of warping as a result of the water damage. ", Cards that exhibit an atypical cut for the issue, which may result in portions of the subject card being cut off or more than one card being visible due to its oversized nature, will be designated "MC.". Psalm 91:10. PSA is a good indicator for prostate problems, but not a good indicator for prostate cancer. Blood levels of PSA can be elevated in men with prostate cancer. If so, you’ll need to think about active treatment. PSA last test 06/2014 was at 6.9 up from 5.8 in January 0f 2014 and free PSA at 10% down from 11%. A PSA VG 3 card reveals some rounding of the corners, though not extreme. For example, if a 1952 Red Man Tobacco card is cut at or outside of the established tab line, the card would be eligible to receive a numerical grade. More biopsies, no malignancies again. Review. The corners and edges of the contained cards may be exposed; however, the cards must still be held in place by the package and cannot show any evidence of removal. For instance, I know someone whose PSA is around 20, and despite lots of tests, no cancer can be found. The seal may be heavily worn and the pack may be visibly soiled. PSA PR-FR 1 pack is a pack that exhibits similar attributes to a PSA Good 2 but it may possess some additional, severe flaws. Heavy staining, paper loss, fading and numerous print defects may be present. So, in a case like this, the pack graders will take that particular year into consideration before rendering their opinion. the eye appeal of the card is good. In other words, the borders must be virtually full in order for a grade to be rendered. Centering must be 85/15 or better on the front and 90/10 or better on the back. Let's say you have a 1955 Topps Sandy Koufax rookie card that is right on the edge of the acceptable guidelines for centering in a particular grade. It’s the only way to be sure you have cancer. You will not be charged the grading fee. But PSA results aren’t always reliable, and sometimes doctors aren’t sure what they mean. Simply put, when PSA assigns a numerical grade to a certified autograph, it is setting that autograph apart in the market. The higher the PSA level, the greater the inflammation. PSA is a protein made by prostate tissue. Focus may be somewhat off-register and edges may exhibit noticeable wear. Cards that are cut within the limits established for a particular issue will be encapsulated and designated as "authentic" by PSA. For instance, a faint impression from a paper clip would be an example of this type of acceptable defect. Prostate-specific antigen (PSA) is a protein made in the prostate. What is your opinion. At worst it’s the same grade and from my experience getting a bgs 9.5 is slightly harder than a psa 10. PSA is prostate specific antigen, a protein made by prostate cells that shows up in your blood with a PSA blood test. Well, take this example. Loss of original gloss will be more apparent. That would mean that, even if there were cancer, it might be better thought of as the kind more typical of a PSA up to 10 rather than a PSA over 10. Two light surface abrasions may be present. Tickets having significant flaws will receive a "qualified" grade as follows: First and foremost, authentication is the most crucial step to the PSA grading process. The doctor will send the sample to a lab. Slight wax staining is acceptable on the back of the card only. Some surface wear will be apparent, along with possible light scuffing or light scratches. Centering must be approximately 60/40 to 65/35 or better on the front and 90/10 or better on the reverse. The relative survival rate of prostate cancer for 10 years is around 90%. A PSA NM-MT 8 pack is a pack that exhibits similar attributes to a PSA Mint 9 but it may possess one or more of the following technical imperfections upon close inspection: slight wear at one or two corners, a pin-sized hole at one of the corners, a wrinkle in the surface of the wax/cellophane wrapping, slight toning or soiling on the seal, very slight toning of the wrapper itself and/or a slight centering imperfection to the wrap. Levels above 4 ng/mL but less than 10 ng/mL are considered suspicious. Although most of it is released through semen, a small amount of PSA can be found in blood. In other words, noticeable fading may prevent a ticket from reaching Gem Mint status. Biopsies were performed for those with PSA levels greater than 10.0 ng/mL or with a PSA velocity of 1.0 ng/mL or greater in consecutive screening. A PSA NM 7 is a card with just a slight surface wear visible upon close inspection. It is part of the male reproductive system, and produces the protein PSA. Continued What Your PSA Numbers Mean. Centering, as in an EX-MT 6, must be 70/30 or better, on the front and back. So the higher the percentage, the less chance there is of the PSA being caused by prostate cancer. On that point ALMOST ALL of my psa 10s that did cross to bgs 9.5 were minimum gem(3×9.5 and 1×9 subgrade). The image must be centered on the card within a tolerance not to exceed approximately 55/45 to 60/40 percent on the front, and 75/25 percent on the reverse. The Meaning of high or elevated PSA levels. For example, a card that meets all of the other requirements for PSA MINT 9 and measures 60/40 off-center PSA … One or two non-game related punctures or holes may be present. There may be minor chipping on edges. This test can help doctors to diagnose problems with the prostate, including cancer. Centering must be approximately 70/30 to 75/25 or better on the front and 90/10 or better on the back. In some cases, no excess tearing (beyond the acceptable limits for a stub) will be allowed within a particular grade. Severe water damage may be present where it has seeped into the pack itself, affecting the cards contained within. A PSA Poor 1 will exhibit many of the same qualities of a PSA Fair 1.5 but the defects may have advanced to such a serious stage that the eye appeal of the card has nearly vanished in its entirety. A cello pack may have a couple of severe splits through the protective wrapping as long as all the contained cards are held securely in their package. 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